Business Network New York
Companies:51,220
Products and Services:2,873
Articles and publications:31,070 (+1)
Tenders & Vacancies:17

Uncovering clues as to why Progressive Neurogenerative disease - ALS – spontaneously reverses
Information may not be reliable

11/28/2021
GenieUs Genomics Sydney and Duke University North Carolina have embarked on a pilot study to look at the biologic mechanisms in patients that have spontaneously reversed ALS.

Amyotrophic Lateral Sclerosis (ALS), is a progressive neurodegenerative disease that causes muscle weakness, paralysis, and ultimately, respiratory failure. An ALS reversal is a person who has regained significant or complete motor function having previously been diagnosed with ALS. 

 

The study aims to look at the patient’s motor neurons to potentially uncover new clues as to why these patients have reversed the disease. Illumina will be supporting the study by providing in depth genomic sequencing for the project.

 

The study will be run by Professor Rick Bedlack who has been following this group of patients in the hope of uncovering a mechanism that can then be targeted as a therapeutic or diagnostic target.

 

There are 54 patients across the world that have spontaneously reversed ALS.

Their ALS diagnosis, progression and recovery have all been independently confirmed by Dr. Bedlack and his team at Duke. Some of these patients were unable to speak, swallow, breath or walk independently and now have regained those lost functions

 

No one knows why this occurs but there are three prevailing schools of thought.

 

1.    That their ALS has been misdiagnosed and they instead had some novel, previously undescribed mimic-syndrome

2.    That the treatments they took actually worked

3.    That there is a biological mechanism that is unique that helps flip the disease back under threshold.

 

It is the last theory that GenieUs and Duke University want to investigate in a pilot study. Similar findings have already been made in diseases like Alzheimers. In 2018, Dr Eric Reinman and his team recently uncovered a mutation in an Alzhiemer’s patient that seems to interfere with the ability of two key proteins to bind together—a binding that seems to be crucial for the progression of the deadly neural cascade. Even though this woman had classic amyloid plaques associated with Alzheimer’s she didn’t suffer the traditional Alzheimer’s symptoms. Reiman and his colleagues demonstrated they could replicate this effect in the lab using small molecule drugs that consist of antibodies which interfere with the binding in a similar way

 

It is this kind of process that the teams at Duke University and GenieUs Genomics hope to uncover and translate for ALS.

 

Founded in 2017, GenieUs’ analytics solution is at the forefront of bioanalytical interrogation of  datasets to map and sub-categorise neurodegenerative diseases for more personalised treatment options.  Neurodegenerative diseases are complex and vary between people, so it is important to understand  the unique genetic backgrounds and molecular events that cause the condition and create truly personalised care and treatment for people.

 

Matt Keon, CEO and co-founder of GenieUs, said: “A large component of ALS still remains a mystery. If we can solve bigger pieces of the puzzle, in this case uncover a new mechanism to target then we are a step closer to solving ALS in a very real, tangible way .”

 

Rick Bedlack, Professor, Duke University said: “I am grateful to collaborate with the brilliant GenieUS team to uncover the mechanisms of ALS reversals.  If we can understand why these recoveries happened, we might be able to make them happen more often.”

 

Amanda Cashin, PhD, co-founder & Global Head, Illumina For Startups said:

“We are pleased to award Matt Keon and his team at GenieUs an Illumina for Startups Sequencing Grant to progress their research into finding a therapeutic or diagnostic target for generate proof-of-concept data towards development of a personalised approach to diagnosis and treatment of neurogenerative disease - ALS. GenieUs is the first startup in Australia to be awarded this grant from Illumina to access our sequencing systems, reagents and technical expertise at the recently open Illumina Innovation Collective lab in Melbourne,’

 

-ENDS-

 

About GenieUs

GenieUs is a science and technology company using breakthrough data analytics and machine learning to solve the mystery of neurodegenerative diseases, one of the most misunderstood condition areas on the planet. Founded in 2017, its analytics solution uses cutting-edge algorithms and the deepest integration of datasets to map and sub-categorise neurodegenerative diseases for more personalised treatment.

 

About Neurodegenerative Disease

Neurodegenerative diseases like motor neuron diseases and dementia are one of our fastest-growing health risks. There are 10 million new cases of dementia globally every year, yet research and diagnosis are years behind diseases like cancer.

 

###

view all (2604)

Other articles and publications:

Regardless of the reason, why do breakups hurt even when you wanted it? You are not alone and such as the manifestations of people who have been hurt andheartbroken.
9/22/2019
Why Study In Japan?
Information may not be reliable
Du học MAP là trung tâm tư vấn du học Nhật Bảnhàng đầu Việt Nam. Với 12 năm kinh nghiệm, MAP Education luôn là địa chỉ được các bậc phụ huynh và các em học sinh trao trọn niềm tin.
11/5/2019
Left untreated, approximately 20% of AK lesions progress to squamous cell carcinoma.
7/22/2021
These are encouraging early findings and we hope that we will be able to collect enough evidence to be able to move into clinical trials in the very near future. ”
11/29/2021
NASDAQ Company offers Life Saving Medical Advances; AI & Immunotherapy for Cancer & Immune Related Diseases Including COVID-19: Avalon GloboCare Corp. (NASDAQ: AVCO)
2/17/2022
This book adds another feather to the surprise package that she packs in her books.
8/28/2022

Articles and publications of other companies:

YNM is committed to providing high-end technology bed lines and products for customers, and build a solid base and pleasant sleeping atmosphere for every user.
11/27/2018
Yogi Women; The Hottest New Arrivals
Information may not be reliable
Who said luxury cannot be casual? Introducing smart joggers and leggings, more elegant and more versatile like never before.
11/27/2018
Rushing Speed is now offering you high-quality CNC routers. The CNC router gives you to simplify working process technology and easily fix working pieces. It reduces the cost of labor also.
11/27/2018
All Natural Kidney Health & Kidney Function Restoration Program is a kidney health reversal program through natural remedies for the patients suffering from kidney problems.
5/29/2019
Vancouver’s best commercial and residential cleaning services company EcoGREEN Cleaning has launched a new website and online booking platform to serve its customers better. .
6/6/2019
Winnix Technologies is one of the most reliable providers of superior quality UHF RFID products like OEM/Embedded reader module, RFID readers, RFID antennas and RFID tags in China
6/9/2019
Business details
  • +1 (516) 547-0884
  • USA
I am 5 years experience of seo in digital marketing
×